brain 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term brain 1
UniProt ID PO3F3_MOUSE
Name OTF-8
Octamer-binding transcription factor 8
Brain-specific homeobox/POU domain protein 1
Oct-8
Octamer-binding protein 8
Brain-1
Brn-1
POU domain, class 3, transcription factor 3
Gene Names Pou3f3
Taxonomy Mus musculus

General annotation

Function Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3').
Subcellular location Nucleus.

Gene Ontology

GO:0008284 positive regulation of cell proliferation BP
GO:0072240 metanephric DCT cell differentiation BP
GO:0021869 forebrain ventricular zone progenitor cell division BP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0072233 metanephric thick ascending limb development BP
GO:0043066 negative regulation of apoptotic process BP
GO:0006351 transcription, DNA-dependent BP
GO:0021799 cerebral cortex radially oriented cell migration BP
GO:0045892 negative regulation of transcription, DNA-dependent BP
GO:0072227 metanephric macula densa development BP
GO:0072218 metanephric ascending thin limb development BP
GO:0071837 HMG box domain binding MF
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0005634 nucleus CC
GO:0043565 sequence-specific DNA binding MF

Sequence

>gi|112421036|ref|NP_032926.2| POU domain, class 3, transcription factor 3 [Mus musculus]
MATAASNPYLPGNSLLTAGSIVHSDAAGAGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVK
MVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPP
PPPQGPDVKGGAGREDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAG
GQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPH
PPHPHHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN
VFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALES
HFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHH
GLQTSVQ

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Database Cross Reference

Ensembl Gene ENSMUST00000054883
UniGene
PDB
RefSeq NP_032926.2
Pfam PF00046
PF00157