brain 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term brain 1
UniProt ID PO3F3_RAT
Name POU domain, class 3, transcription factor 3
Brain-specific homeobox/POU domain protein 1
Brain-1
Brn-1
Gene Names Pou3f3
Taxonomy Rattus norvegicus

General annotation

Function Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).
Subcellular location Nucleus.

Gene Ontology

GO:0072240 metanephric DCT cell differentiation BP
GO:0007399 nervous system development BP
GO:0043066 negative regulation of apoptotic process BP
GO:0000122 negative regulation of transcription from RNA polymerase II promoter BP
GO:0072227 metanephric macula densa development BP
GO:0043565 sequence-specific DNA binding MF
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0072233 metanephric thick ascending limb development BP
GO:0072218 metanephric ascending thin limb development BP
GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity MF
GO:0005634 nucleus CC
GO:0008284 positive regulation of cell proliferation BP

Sequence

>gi|20301970|ref|NP_620192.1| POU domain, class 3, transcription factor 3 [Rattus norvegicus]
MATAASNPYLPGNSLLAAGSIVHSDAAGAGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVK
MVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPRPPP
PPPQGPDVKGGVGREDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAG
GQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPH
PPHPHHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGN
VFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALES
HFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHH
GLQTSVQ

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.11354
PDB
RefSeq NP_620192.1
Pfam PF00046
PF00157