CB1

General Information (Source: NCBI Gene,UniProt)

Text mining Term CB1
UniProt ID CNR1_RAT
Name Brain-type cannabinoid receptor
CB-R
Cannabinoid receptor 1
CB1
Gene Names Cnr1
Synonyms:Skr6
Taxonomy Rattus norvegicus

General annotation

Function Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0008144 drug binding MF
GO:0032228 regulation of synaptic transmission, GABAergic BP
GO:0006950 response to stress BP
GO:0045777 positive regulation of blood pressure BP
GO:0060135 maternal process involved in female pregnancy BP
GO:0007613 memory BP
GO:0043278 response to morphine BP
GO:0031622 positive regulation of fever generation BP
GO:0007568 aging BP
GO:0045471 response to ethanol BP
GO:0045776 negative regulation of blood pressure BP
GO:0042220 response to cocaine BP
GO:0031999 negative regulation of fatty acid beta-oxidation BP
GO:0007584 response to nutrient BP
GO:0043065 positive regulation of apoptotic process BP
GO:0060259 regulation of feeding behavior BP
GO:0004949 cannabinoid receptor activity MF
GO:0060405 regulation of penile erection BP
GO:0033004 negative regulation of mast cell activation BP
GO:0007283 spermatogenesis BP
GO:0010976 positive regulation of neuron projection development BP
GO:0035094 response to nicotine BP
GO:0005515 protein binding MF
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger BP
GO:0005886 plasma membrane CC
GO:0016021 integral to membrane CC
GO:0019233 sensory perception of pain BP
GO:0043271 negative regulation of ion transport BP
GO:0051001 negative regulation of nitric-oxide synthase activity BP
GO:0032496 response to lipopolysaccharide BP
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus BP
GO:0033602 negative regulation of dopamine secretion BP
GO:0050796 regulation of insulin secretion BP
GO:0045759 negative regulation of action potential BP
GO:0051966 regulation of synaptic transmission, glutamatergic BP

Sequence

>gi|6978673|ref|NP_036916.1| cannabinoid receptor 1 [Rattus norvegicus]
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPL
VPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLC
VILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFL
TAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFW
IGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL
VVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000010850
UniGene Rn.89774
PDB
RefSeq NP_036916.1
Pfam PF00001