| Text mining Term | gephyrin |
|---|---|
| UniProt ID | GEPH_RAT |
| Name |
MPT adenylyltransferase Molybdopterin adenylyltransferase Molybdopterin molybdenumtransferase Putative glycine receptor-tubulin linker protein Domain E Domain G Gephyrin MPT Mo-transferase |
| Gene Names |
Gphn
Synonyms:Gph |
| Taxonomy | Rattus norvegicus |
| Function |
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
|---|---|
| Subcellular location |
Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Cytoplasmic face of glycinergic postsynaptic membranes. |
| GO:0051260 | protein homooligomerization | BP |
| GO:0007416 | synapse assembly | BP |
| GO:0030054 | cell junction | CC |
| GO:0042803 | protein homodimerization activity | MF |
| GO:0005102 | receptor binding | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0005856 | cytoskeleton | CC |
| GO:0005886 | plasma membrane | CC |
| GO:0015631 | tubulin binding | MF |
| GO:0016740 | transferase activity | MF |
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | BP |
| GO:0006605 | protein targeting | BP |
| GO:0046872 | metal ion binding | MF |
| GO:0045211 | postsynaptic membrane | CC |
| GO:0030674 | protein binding, bridging | MF |
| GO:0005524 | ATP binding | MF |
| GO:0060077 | inhibitory synapse | CC |
| GO:0032947 | protein complex scaffold | MF |
>gi|88853561|ref|NP_074056.2| gephyrin [Rattus norvegicus] MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETL IDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTL IINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGV QCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLS TASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDG MGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCG ADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGV TEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNE GISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVS AVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRL MSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11032 |
| PDB |
2FTS 2FU3 1T3E 1IHC |
| RefSeq |
NP_074056.2 |
| Pfam |
PF03454 PF03453 PF00994 |