glial glutamate transporter

General Information (Source: NCBI Gene,UniProt)

Text mining Term glial glutamate transporter
UniProt ID EAA1_RAT
Name Glial glutamate transporter
Excitatory amino acid transporter 1
GLAST-1
Sodium-dependent glutamate/aspartate transporter 1
Solute carrier family 1 member 3
Gene Names Slc1a3
Synonyms:Eaat1
Taxonomy Rattus norvegicus

General annotation

Function Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0045202 synapse CC
GO:0017153 sodium MF
GO:0006836 neurotransmitter transport BP
GO:0005314 high-affinity glutamate transmembrane transporter activity MF
GO:0010035 response to inorganic substance BP
GO:0016323 basolateral plasma membrane CC
GO:0005624 membrane fraction CC
GO:0005743 mitochondrial inner membrane CC
GO:0016021 integral to membrane CC
GO:0043197 dendritic spine CC
GO:0043490 malate-aspartate shuttle BP

Sequence

>gi|9507115|ref|NP_062098.1| excitatory amino acid transporter 1 [Rattus norvegicus]
MTKSNGEEPRMGSRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVSAVIVGTILGFALRP
YKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGII
IVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEKRSFKVPIQANETLL
GAVINNVSEAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMR
LVAVIMWYAPLGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIG
GLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFD
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLG
AGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNEPEKPVADSETKM

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Database Cross Reference

Ensembl Gene ENSRNOT00000035821
UniGene Rn.34134
PDB
RefSeq NP_062098.1
Pfam PF00375