factor A

General Information (Source: NCBI Gene,UniProt)

Text mining Term factor A
UniProt ID GSK3A_RAT
Name Factor A
Serine/threonine-protein kinase GSK3A
Glycogen synthase kinase-3 alpha
FA
GSK-3 alpha
Gene Names Gsk3a
Taxonomy Rattus norvegicus

General annotation

Function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity).
Subcellular location

Gene Ontology

GO:0034236 protein kinase A catalytic subunit binding MF
GO:0007399 nervous system development BP
GO:0005977 glycogen metabolic process BP
GO:0050321 tau-protein kinase activity MF
GO:0004674 protein serine/threonine kinase activity MF
GO:0005829 cytosol CC
GO:0005524 ATP binding MF
GO:0016055 Wnt receptor signaling pathway BP

Sequence

>gi|8393496|ref|NP_059040.1| glycogen synthase kinase-3 alpha [Rattus norvegicus]
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPS
GSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAE
TRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFT
KAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYI
CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN
YTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRSLGTQLPNNRPLP
PLFNFSPGELSIQPSLNAILIPPHLRSPSGPATLTSSSQALTETQTGQDWQAPDATPTLTNSS

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Database Cross Reference

Ensembl Gene
UniGene Rn.36807
PDB
RefSeq NP_059040.1
Pfam PF00069