vanilloid receptor 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term	vanilloid receptor 1
UniProt ID	TRPV1_MOUSE
Name	OTRPC1 Transient receptor potential cation channel subfamily V member 1 Vanilloid receptor 1 TrpV1 Osm-9-like TRP channel 1
Gene Names	Trpv1
Taxonomy	Mus musculus

General annotation

Function	Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL (By similarity).
Subcellular location	Cell membrane; Multi-pass membrane protein (By similarity).

Function

Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL (By similarity).

Subcellular location

Cell membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0009408	response to heat	BP
GO:0016021	integral to membrane	CC
GO:0005886	plasma membrane	CC
GO:0005516	calmodulin binding	MF
GO:0005262	calcium channel activity	MF
GO:0006629	lipid metabolic process	BP
GO:0001660	fever generation	BP
GO:0002024	diet induced thermogenesis	BP
GO:0005524	ATP binding	MF
GO:0043005	neuron projection	CC
GO:0009268	response to pH	BP
GO:0042637	catagen	BP
GO:0060083	smooth muscle contraction involved in micturition	BP
GO:0050968	detection of chemical stimulus involved in sensory perception of pain	BP
GO:0002790	peptide secretion	BP
GO:0050954	sensory perception of mechanical stimulus	BP
GO:0048266	behavioral response to pain	BP

Sequence

>gi|47825364|ref|NP_001001445.1| transient receptor potential cation channel subfamily V member 1 [Mus musculus]
MEKWASLDSDESEPPAQENSCPDPPDRDPNSKPPPAKPHIFATRSRTRLFGKGDSEEASPMDCPYEEGGL
ASCPIITVSSVVTLQRSVDGPTCLRQTSQDSVSTGVETPPRLYDRRSIFDAVAQSNCQELESLLSFLQKS
KKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDIARKTDSLKQFVNASYTDSYYKGQTALHIAI
ERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISA
RDSVGNTVLHALVEVADNTADNTKFVTNMYNEILILGAKLHPTLKLEELTNKKGLTPLALAASSGKIGVL
AYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN
RLLQDKWDRFVKRIFYFNFFVYCLYMIIFTTAAYYRPVEGLPPYKLNNTVGDYFRVTGEILSVSGGVYFF
FRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRGF
QQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPVESPPHKCRGSACRPGNSYNS
LYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKL
QRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDFRWCFRVDEVNWTTWNTNVGIINEDPGNCEGV
KRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHSTQPEEVQLKHYTGSLKPEDAEVFKDSMAPGEK

Database Cross Reference

Ensembl Gene	ENSMUST00000102526 ENSMUST00000108470 ENSMUST00000138853 ENSMUST00000006106
UniGene	Mm.447485
PDB
RefSeq	NP_001001445.1
Pfam	PF00023 PF00520

PTID

vanilloid receptor 1

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference