Fc gamma RI

General Information (Source: NCBI Gene,UniProt)

Text mining Term Fc gamma RI
UniProt ID FCGR1_MOUSE
Name IgG Fc receptor I
Fc-gamma RI
FcRI
High affinity immunoglobulin gamma Fc receptor I
Gene Names Fcgr1
Synonyms:Fcg1
Taxonomy Mus musculus

General annotation

Function High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Subcellular location Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G (By similarity).

Gene Ontology

GO:0045087 innate immune response BP
GO:0009897 external side of plasma membrane CC
GO:0001798 positive regulation of type IIa hypersensitivity BP
GO:0006898 receptor-mediated endocytosis BP
GO:0042742 defense response to bacterium BP
GO:0050766 positive regulation of phagocytosis BP
GO:0016021 integral to membrane CC
GO:0007166 cell surface receptor linked signaling pathway BP
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I BP
GO:0001788 antibody-dependent cellular cytotoxicity BP
GO:0019770 IgG receptor activity MF
GO:0001805 positive regulation of type III hypersensitivity BP
GO:0006911 phagocytosis, engulfment BP
GO:0006910 phagocytosis, recognition BP

Sequence

>gi|6753832|ref|NP_034316.1| high affinity immunoglobulin gamma Fc receptor I precursor [Mus musculus]
MILTSFGDDMWLLTTLLLWVPVGGEVVNATKAVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFING
TAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNK
LVYNVVFYRNGKSFQFSSDSEVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSP
FPEGSLVTLNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDSSVLK
RSPELELQVLGPQSSAPVWFHILFYLSVGIMFSLNTVLYVKIHRLQREKKYNLEVPLVSEQGKKANSFQQ
VRSDGVYEEVTATASQTTPKEAPDGPRSSVGDCGPEQPEPLPPSDSTGAQTSQS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000029748
UniGene Mm.150
PDB
RefSeq NP_034316.1
Pfam PF00047