delta aminolevulinic acid dehydratase

General Information (Source: NCBI Gene,UniProt)

Text mining Term delta aminolevulinic acid dehydratase
UniProt ID HEM2_MOUSE
Name ALADH
Delta-aminolevulinic acid dehydratase
Porphobilinogen synthase
Gene Names Alad
Synonyms:Lv
Taxonomy Mus musculus

General annotation

Function Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
Subcellular location

Gene Ontology

GO:0042802 identical protein binding MF
GO:0006783 heme biosynthetic process BP
GO:0008270 zinc ion binding MF
GO:0032791 lead ion binding MF
GO:0004655 porphobilinogen synthase activity MF

Sequence

>gi|34328485|ref|NP_032551.3| delta-aminolevulinic acid dehydratase [Mus musculus]
MHHQSVLHSGYFHPLLRSWQTAASTVSASNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVE
AGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGA
FLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRD
AAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADMLMVKPGLPYLDMVREVKDKHPELPLAVYQVSG
EFAMLWHGAQAGAFDLRTAVLETMTAFRRAGADIIITYFAPQLLKWLKEE

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Database Cross Reference

Ensembl Gene ENSMUST00000107444
ENSMUST00000030090
UniGene Mm.6988
PDB 2Z0I
2Z1B
RefSeq NP_032551.3
Pfam PF00490