phosphoinositide phospholipase C

General Information (Source: NCBI Gene,UniProt)

Text mining Term phosphoinositide phospholipase C
UniProt ID PLCB4_RAT
Name Phospholipase C-beta-4
Phosphoinositide phospholipase C-beta-4
PLC-beta-4
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4
Gene Names Plcb4
Taxonomy Rattus norvegicus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
Subcellular location

Gene Ontology

GO:0016042 lipid catabolic process BP
GO:0051019 mitogen-activated protein kinase binding MF
GO:0035556 intracellular signal transduction BP
GO:0005626 insoluble fraction CC
GO:0007602 phototransduction BP
GO:0005509 calcium ion binding MF
GO:0004435 phosphatidylinositol phospholipase C activity MF
GO:0043267 negative regulation of potassium ion transport BP
GO:0005737 cytoplasm CC
GO:0004871 signal transducer activity MF

Sequence

>gi|13242241|ref|NP_077329.1| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 [Rattus norvegicus]
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRL
AAIPKDPKILAALESVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEITKQWVEGLRSIIHNFRANN
VSPMTCLKKHWMKLAFLTNTSGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFY
ELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEE
LKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVL
LAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYQM
SKYCEDLFGDLLLKQALESHPLEPGRLLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSMMEAGESAAPA
SILEDDNEEEIESAADQEEEAHPEYKFGNELSADDFSHKEAVANSVKKGLVTVEDEQAWMASYKYVGATT
NIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRV
DSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVI
AATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAV
LRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGLGDIVDALSDPK
KFLSITEKRADQLRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAALGSGQEAKK
GIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKIL
EKAMKKKGGSNCLEIKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCEL
LRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFL
EERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.6155
PDB
RefSeq NP_077329.1
Pfam PF00388
PF06631
PF00387
PF09279
PF00168