proton pump

General Information (Source: NCBI Gene,UniProt)

Text mining Term proton pump
UniProt ID AT12A_RAT
Name Non-gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Potassium-transporting ATPase alpha chain 2
Gene Names Atp12a
Synonyms:Atp1al1
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0016324 apical plasma membrane CC
GO:0005524 ATP binding MF
GO:0046872 metal ion binding MF
GO:0006754 ATP biosynthetic process BP
GO:0008900 hydrogen MF
GO:0010038 response to metal ion BP
GO:0016021 integral to membrane CC
GO:0014070 response to organic cyclic compound BP

Sequence

>gi|19424160|ref|NP_598201.1| potassium-transporting ATPase alpha chain 2 [Rattus norvegicus]
MRRKTEIYSVELNGTKDVKPADQRDDKKFKGAKNKDLEPNKSHEKEELKKELDLDDHRLSNTELEQKYGT
NIIQGLSSVRATELLARDGPNTLTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAFVIQYVNNSASLD
NVYLGAILVLVVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVGDVVEIKGGDQ
IPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIG
RIASLASGVGSEKTPIAIEIEHFVHIVAGVAVSIDIIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLA
TVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSENQTK
QAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRTVVGDASETALLKFSEVILGDVMGIRKRNHKVA
EIPFNSTNKFQLSIHETEDPNNKRFLVVMKGAPERILEKCSTIMINGQEQPLDKSSADSFHTAYMELGGL
GERVLGFCHLYLPAEQFPQSYIFDVDSVNFPTSNFCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTG
DHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLTNYQEI
VFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASI
VTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAE
SDIMNRKPRHKKKDRLVNTQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVAWETDDINDL
EDSYGQEWTRYQRKYLEWTGSTAFFVAIMIQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIASQVIVALI
LSYGLGSVPALSFTMLRVQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.9858
PDB
RefSeq NP_598201.1
Pfam PF00689
PF00690
PF00122
PF00702