Pit 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term Pit 1
UniProt ID S20A1_MOUSE
Name Phosphate transporter 1
Leukemia virus receptor 1 homolog
Solute carrier family 20 member 1
GLVR-1
Sodium-dependent phosphate transporter 1
PiT-1
Gibbon ape leukemia virus receptor 1
Gene Names Slc20a1
Taxonomy Mus musculus

General annotation

Function Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).
Subcellular location Membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0004872 receptor activity MF
GO:0005886 plasma membrane CC
GO:0016021 integral to membrane CC
GO:0005315 inorganic phosphate transmembrane transporter activity MF

Sequence

>gi|227430320|ref|NP_001153065.1| sodium-dependent phosphate transporter 1 isoform 2 [Mus musculus]
MESTVATITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILA
SIFETVGSALLGAKVSETIRNGLIDVELYNETQDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGA
TIGFSLVANGQKGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTI
GINLFSIMYTGAPWLKSPRRWLACIHFRRLQASVC

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Database Cross Reference

Ensembl Gene ENSMUST00000028880
ENSMUST00000110315
UniGene Mm.272675
PDB
RefSeq NP_056562.1
NP_001153065.1
Pfam PF01384