Pit 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term	Pit 1
UniProt ID	S20A1_MOUSE
Name	Leukemia virus receptor 1 homolog Sodium-dependent phosphate transporter 1 PiT-1 Gibbon ape leukemia virus receptor 1 Solute carrier family 20 member 1 Phosphate transporter 1 GLVR-1
Gene Names	Slc20a1
Taxonomy	Mus musculus

General annotation

Function	Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).
Subcellular location	Membrane; Multi-pass membrane protein (By similarity).

Function

Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor but do not confer infection susceptibility to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B).

Subcellular location

Membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0016021	integral to membrane	CC
GO:0004872	receptor activity	MF
GO:0005886	plasma membrane	CC
GO:0005315	inorganic phosphate transmembrane transporter activity	MF

Sequence

>gi|7657579|ref|NP_056562.1| sodium-dependent phosphate transporter 1 isoform 1 [Mus musculus]
MESTVATITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILA
SIFETVGSALLGAKVSETIRNGLIDVELYNETQDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGA
TIGFSLVANGQKGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTI
GINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREVKSSPSESPLMEKKS
NLKEDHEETKMAPGDVEHRNPVSEVVCATGPLRAVVEERTVSFKLGDLEEAPERERLPMDLKEETSIDST
INGAVQLPNGNLVQFSQTVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNS
YTSYTMAICGMPLDSFRAKEGEQKGDEMETLTWPNADTKKRIRMDSYTSYCNAVSDLHSESEMDMSVKAE
MGLGDRKGSSGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYKQEASTKA
ATPIWLLLYGGVGICMGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVG
SVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAVFKYIILPV

Database Cross Reference

Ensembl Gene	ENSMUST00000028880 ENSMUST00000110315
UniGene	Mm.272675
PDB
RefSeq	NP_001153065.1 NP_056562.1
Pfam	PF01384

PTID

Pit 1

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference