proton pump

General Information (Source: NCBI Gene,UniProt)

Text mining Term proton pump
UniProt ID AT12A_MOUSE
Name Proton pump
Potassium-transporting ATPase alpha chain 2
Non-gastric H(+)/K(+) ATPase subunit alpha
Gene Names Atp12a
Synonyms:Atp1al1
Taxonomy Mus musculus

General annotation

Function Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0006754 ATP biosynthetic process BP
GO:0016021 integral to membrane CC
GO:0055075 potassium ion homeostasis BP
GO:0008900 hydrogen MF
GO:0046872 metal ion binding MF
GO:0005524 ATP binding MF

Sequence

>gi|157168326|ref|NP_619593.2| potassium-transporting ATPase alpha chain 2 [Mus musculus]
MRRKTEIYSVELNGTKDVELADQKDDKKFKGGKNKDSEPNKSQEEELKKELDLDDHRLSNTDLEQKYGTN
IIQGLSSIRAAELLARDGPNALTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAYVIQYVSSTASLDN
VYLGAILVLVVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKIIPAEQLVVGDVVEIKGGDQI
PADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGR
IASLASGVGSEKTPIAIEIEHFVHIVAAVAVSVGVIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLAT
VTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSENQTKQ
AFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRVVVGDASETALLKFSEVILGDVMDIRKRNHKVAE
IPFNSTNKFQLSIHETEDPNDKRFLMVMKGAPERILEKCSTIMINGQEQPLDKSSADAFHTAYMELGGLG
ERVLGFCHLYLPADKFPQSYTFDVDSINFPTSNLCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGD
HPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLINYQEIV
FARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIV
TGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAES
DIMNRKPRHKKKDRLVNKQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVSWETDDINDLE
DSYGQEWTRYQRKYLEWTGSTAFFVAIMVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIISQIIVALVL
SYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000007340
UniGene Mm.273271
PDB
RefSeq NP_619593.2
Pfam PF00702
PF00689
PF00690
PF00122