phosphoinositide phospholipase C

General Information (Source: NCBI Gene,UniProt)

Text mining Term phosphoinositide phospholipase C
UniProt ID PLCG2_RAT
Name PLC-gamma-2
Phosphoinositide phospholipase C-gamma-2
Phospholipase C-IV
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
PLC-IV
Phospholipase C-gamma-2
Gene Names Plcg2
Taxonomy Rattus norvegicus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Subcellular location

Gene Ontology

GO:0009395 phospholipid catabolic process BP
GO:0004871 signal transducer activity MF
GO:0033198 response to ATP BP
GO:0005515 protein binding MF
GO:0035556 intracellular signal transduction BP
GO:0032026 response to magnesium ion BP
GO:0007204 elevation of cytosolic calcium ion concentration BP
GO:0004435 phosphatidylinositol phospholipase C activity MF
GO:0005624 membrane fraction CC

Sequence

>gi|8393984|ref|NP_058864.1| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 [Rattus norvegicus]
MTTMVNVDTLPEYEKSQIKRALELGTVMTVFSARKSTPERRTVQMIMETRQVAWSKTADKIEGFLDIMEI
KEIRPGKNSKDFERAKAVRHKADCCFTIFYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMNASTPT
MIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLM
FEQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRET
AEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLR
AGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKV
FKEVLGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQGELYMWDSIDQK
WTRHYCAIADAKLSFSDDIEQTVEEDPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYCAETGAKDGT
FLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELR
LTDPVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGR
HFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMP
QRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKI
DTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQK
GLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRSEKYDP
MPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKV
TFEIYDPNLAFLRFLVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVL
ESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLRLYQEKCNRRLREKRVSN
SRFYS

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.9751
PDB 2EOB
RefSeq NP_058864.1
Pfam PF00168
PF00388
PF09279
PF00018
PF00017
PF00387