fibroblast growth factor 23

General Information (Source: NCBI Gene,UniProt)

Text mining Term fibroblast growth factor 23
UniProt ID FGF23_MOUSE
Name Fibroblast growth factor 23
FGF-23
Gene Names Fgf23
Taxonomy Mus musculus

General annotation

Function Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Upregulates EGR1 expression in the presence of KL.
Subcellular location Secreted (By similarity). Note=Secretion is dependent on O-glycosylation (By similarity).

Gene Ontology

GO:0030154 cell differentiation BP
GO:0046888 negative regulation of hormone secretion BP
GO:0045893 positive regulation of transcription, DNA-dependent BP
GO:0005105 type 1 fibroblast growth factor receptor binding MF
GO:0070374 positive regulation of ERK1 and ERK2 cascade BP
GO:0030643 cellular phosphate ion homeostasis BP
GO:0008083 growth factor activity MF
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway BP

Sequence

>gi|12083589|ref|NP_073148.1| fibroblast growth factor 23 precursor [Mus musculus]
MLGTCLRLLVGVLCTVCSLGTARAYPDTSPLLGSNWGSLTHLYTATARTSYHLQIHRDGHVDGTPHQTIY
SALMITSEDAGSVVITGAMTRRFLCMDLHGNIFGSLHFSPENCKFRQWTLENGYDVYLSQKHHYLVSLGR
AKRIFQPGTNPPPFSQFLARRNEVPLLHFYTVRPRRHTRSAEDPPERDPLNVLKPRPRATPVPVSCSREL
PSAEEGGPAASDPLGVLRRGRGDARGGAGGADRCRPFPRFV

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene ENSMUST00000000186
UniGene Mm.347933
PDB
RefSeq NP_073148.1
Pfam PF00167