klotho

General Information (Source: NCBI Gene,UniProt)

Text mining Term klotho
UniProt ID KLOT_MOUSE
Name Klotho peptide
Klotho
Gene Names Kl
Taxonomy Mus musculus

General annotation

Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Subcellular location Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. Isoform 2: Secreted. Klotho peptide: Secreted.

Gene Ontology

GO:0005104 fibroblast growth factor receptor binding MF
GO:0007568 aging BP
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway BP
GO:0005975 carbohydrate metabolic process BP
GO:0006112 energy reserve metabolic process BP
GO:0004566 beta-glucuronidase activity MF
GO:0017134 fibroblast growth factor binding MF
GO:0043169 cation binding MF
GO:0016021 integral to membrane CC
GO:0005886 plasma membrane CC
GO:0005576 extracellular region CC

Sequence

>gi|227330584|ref|NP_038851.2| klotho precursor [Mus musculus]
MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWARFARAPAPEAAGLLHDTFPDGFLWA
VGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPSDSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEG
LRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWA
NRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKV
WHLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYPESMKNNLSSL
LPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQLLSWIDLEYNHPPIFIVENGWF
VSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKEL
LPKSSALFYQKLIEDNGFPPLPENQPLEGTFPCDFAWGVVDNYVQVDTTLSQFTDPNVYLWDVHHSKRLI
KVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNHTVLHFYRCMISELVH
ANITPVVALWQPAAPHQGLPHALAKHGAWENPHTALAFADYANLCFKELGHWVNLWITMNEPNTRNMTYR
AGHHLLRAHALAWHLYDDKFRAAQKGKISIALQADWIEPACPFSQNDKEVAERVLEFDIGWLAEPIFGSG
DYPRVMRDWLNQKNNFLLPYFTEDEKKLVRGSFDFLAVSHYTTILVDWEKEDPMKYNDYLEVQEMTDITW
LNSPSQVAVVPWGLRKVLNWLRFKYGDLPMYVTANGIDDDPHAEQDSLRIYYIKNYVNEALKAYVLDDIN
LCGYFAYSLSDRSAPKSGFYRYAANQFEPKPSMKHYRKIIDSNGFLGSGTLGRFCPEEYTVCTECGFFQT
RKSLLVFISFLVFTFIISLALIFHYSKKGQRSYK

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Database Cross Reference

Ensembl Gene ENSMUST00000078856
UniGene Mm.6500
PDB
RefSeq NP_038851.2
Pfam PF00232