transforming growth factor alpha

General Information (Source: NCBI Gene,UniProt)

Text mining Term transforming growth factor alpha
UniProt ID TGFA_RAT
Name Transforming growth factor alpha
TGF-alpha
EGF-like TGF
ETGF
Protransforming growth factor alpha
TGF type 1
Gene Names Tgfa
Taxonomy Rattus norvegicus

General annotation

Function TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Subcellular location Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.

Gene Ontology

GO:0005615 extracellular space CC
GO:0043526 neuroprotection BP
GO:0051480 cytosolic calcium ion homeostasis BP
GO:0050679 positive regulation of epithelial cell proliferation BP
GO:0007173 epidermal growth factor receptor signaling pathway BP
GO:0005829 cytosol CC
GO:0001934 positive regulation of protein phosphorylation BP
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity BP
GO:0005887 integral to plasma membrane CC
GO:0006916 anti-apoptosis BP
GO:0042493 response to drug BP
GO:0045840 positive regulation of mitosis BP
GO:0004708 MAP kinase kinase activity MF
GO:0005634 nucleus CC
GO:0005154 epidermal growth factor receptor binding MF
GO:0051781 positive regulation of cell division BP
GO:0043524 negative regulation of neuron apoptosis BP
GO:0000187 activation of MAPK activity BP
GO:0042060 wound healing BP
GO:0008083 growth factor activity MF

Sequence

>gi|6981646|ref|NP_036803.1| protransforming growth factor alpha preproprotein [Rattus norvegicus]
MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPAC
VCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHE
KPSALLKGRTACCHSETVV

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Database Cross Reference

Ensembl Gene ENSRNOT00000057441
UniGene Rn.9952
PDB
RefSeq NP_036803.1
Pfam