phosphoinositide phospholipase C

General Information (Source: NCBI Gene,UniProt)

Text mining Term phosphoinositide phospholipase C
UniProt ID PLCB1_MOUSE
Name PLC-beta-1
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
Phospholipase C-beta-1
Phosphoinositide phospholipase C-beta-1
PLC-154
Gene Names Plcb1
Synonyms:Plcb
Taxonomy Mus musculus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity).
Subcellular location

Gene Ontology

GO:0001556 oocyte maturation BP
GO:0048639 positive regulation of developmental growth BP
GO:0042803 protein homodimerization activity MF
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway BP
GO:0045893 positive regulation of transcription, DNA-dependent BP
GO:0032417 positive regulation of sodium BP
GO:0019899 enzyme binding MF
GO:0016607 nuclear speck CC
GO:0000086 G2/M transition of mitotic cell cycle BP
GO:0045663 positive regulation of myoblast differentiation BP
GO:0007613 memory BP
GO:0046330 positive regulation of JNK cascade BP
GO:0030218 erythrocyte differentiation BP
GO:0007215 glutamate signaling pathway BP
GO:0040019 positive regulation of embryonic development BP
GO:0007155 cell adhesion BP
GO:0035722 interleukin-12-mediated signaling pathway BP
GO:0080154 regulation of fertilization BP
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding MF
GO:0035723 interleukin-15-mediated signaling pathway BP
GO:0032735 positive regulation of interleukin-12 production BP
GO:2000438 negative regulation of monocyte extravasation BP
GO:0016042 lipid catabolic process BP
GO:0046488 phosphatidylinositol metabolic process BP
GO:0000790 nuclear chromatin CC
GO:0045892 negative regulation of transcription, DNA-dependent BP
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway BP
GO:0035724 CD24 biosynthetic process BP
GO:0051318 G1 phase BP
GO:0008286 insulin receptor signaling pathway BP
GO:0035556 intracellular signal transduction BP
GO:0030225 macrophage differentiation BP
GO:0048009 insulin-like growth factor receptor signaling pathway BP
GO:0045444 fat cell differentiation BP
GO:0005886 plasma membrane CC
GO:0005516 calmodulin binding MF
GO:0004871 signal transducer activity MF
GO:0006397 mRNA processing BP
GO:0060466 activation of meiosis involved in egg activation BP
GO:2000344 positive regulation of acrosome reaction BP
GO:0005521 lamin binding MF
GO:0004435 phosphatidylinositol phospholipase C activity MF
GO:0021987 cerebral cortex development BP

Sequence

>gi|224967068|ref|NP_062651.2| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 isoform 2 [Mus musculus]
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVK
DARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATN
LLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPD
VYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEP
NSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR
QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTY
SDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKK
RNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVD
LAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVD
MFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPG
YHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTI
EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEP
SSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQ
NNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKR
QEKLVEKHNEIRQQILDEKPKGEGPSSVLSEGCHEDPSVPPNFTPPNPQALKW

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000110116
ENSMUST00000070724
UniGene Mm.330607
PDB
RefSeq NP_001139302.1
NP_062651.2
Pfam PF09279
PF08703
PF00387
PF06631
PF00168
PF00388