glucose 6 phosphatase

General Information (Source: NCBI Gene,UniProt)

Text mining Term glucose 6 phosphatase
UniProt ID G6PC_MOUSE
Name G-6-Pase
Glucose-6-phosphatase
G6Pase
Gene Names G6pc
Synonyms:G6pt
Taxonomy Mus musculus

General annotation

Function Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology

GO:0006094 gluconeogenesis BP
GO:0046415 urate metabolic process BP
GO:0051156 glucose 6-phosphate metabolic process BP
GO:0008202 steroid metabolic process BP
GO:0042593 glucose homeostasis BP
GO:0016021 integral to membrane CC
GO:0005789 endoplasmic reticulum membrane CC
GO:0005980 glycogen catabolic process BP
GO:0035264 multicellular organism growth BP
GO:0016773 phosphotransferase activity, alcohol group as acceptor MF
GO:0004346 glucose-6-phosphatase activity MF
GO:0006641 triglyceride metabolic process BP
GO:0042632 cholesterol homeostasis BP
GO:0005792 microsome CC
GO:0015760 glucose-6-phosphate transport BP
GO:0010468 regulation of gene expression BP

Sequence

>gi|31982353|ref|NP_032087.2| glucose-6-phosphatase [Mus musculus]
MEEGMNILHDFGIQSTRYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLKETVGINLLWVAVVGDW
FNLVFKWILFGQRPYWWVLDTDYYSNSSVPIIKQFPVTCETGPGSPSGHAMGAAGVYYVMVTSTLAIFRG
KKKPTYGFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVAETFSHIRGIYNASLRKYC
LITIFLFGFALGFYLLLKGLGVDLLWTLEKAKRWCERPEWVHLDTTPFASLFKNLGTLLGLGLALNSSMY
RKSCKGELSKLLPFRFACIVASLVLLHLFDSLKPPSQVELIFYILSFCKSATVPFASVSLIPYCLARILG
QTHKKSL

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Database Cross Reference

Ensembl Gene ENSMUST00000019469
UniGene Mm.18064
PDB
RefSeq NP_032087.2
Pfam PF01569