interleukin 3

General Information (Source: NCBI Gene,UniProt)

Text mining Term interleukin 3
UniProt ID IL3_MOUSE
Name Interleukin-3
MCGF
Hematopoietic growth factor
IL-3
Multipotential colony-stimulating factor
Mast cell growth factor
P-cell-stimulating factor
Gene Names Il3
Taxonomy Mus musculus

General annotation

Function Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
Subcellular location Secreted.

Gene Ontology

GO:0019221 cytokine-mediated signaling pathway BP
GO:0008083 growth factor activity MF
GO:0033026 negative regulation of mast cell apoptosis BP
GO:0045885 positive regulation of survival gene product expression BP
GO:0006110 regulation of glycolysis BP
GO:0035304 regulation of protein dephosphorylation BP
GO:0005615 extracellular space CC
GO:0046330 positive regulation of JNK cascade BP
GO:0002763 positive regulation of myeloid leukocyte differentiation BP
GO:0070668 positive regulation of mast cell proliferation BP
GO:0005135 interleukin-3 receptor binding MF
GO:0005125 cytokine activity MF
GO:0010507 negative regulation of autophagy BP
GO:0006955 immune response BP
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation BP
GO:0001666 response to hypoxia BP
GO:0033028 myeloid cell apoptosis BP

Sequence

>gi|31982791|ref|NP_034686.2| interleukin-3 precursor [Mus musculus]
MVLASSTTSIHTMLLLLLMLFHLGLQASISGRDTHRLTRTLNCSSIVKEIIGKLPEPELKTDDEGPSLRN
KSFRRVNLSKFVESQGEVDPEDRYVIKSNLQKLNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLND
LETVLTSRPPQPASGSVSPNRGTVEC

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Database Cross Reference

Ensembl Gene ENSMUST00000019058
UniGene Mm.983
PDB 2L3O
RefSeq NP_034686.2
Pfam PF02059