| Text mining Term | phosphoinositide phospholipase C |
|---|---|
| UniProt ID | PLCG1_RAT |
| Name |
PLC-gamma-1 Phospholipase C-gamma-1 Phosphoinositide phospholipase C-gamma-1 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 |
| Gene Names |
Plcg1
|
| Taxonomy | Rattus norvegicus |
| Function |
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). |
|---|---|
| Subcellular location |
Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment (By similarity). |
| GO:0032236 | positive regulation of calcium ion transport via store-operated calcium channel activity | BP |
| GO:0005737 | cytoplasm | CC |
| GO:0005158 | insulin receptor binding | MF |
| GO:0042542 | response to hydrogen peroxide | BP |
| GO:0004435 | phosphatidylinositol phospholipase C activity | MF |
| GO:0051219 | phosphoprotein binding | MF |
| GO:0071364 | cellular response to epidermal growth factor stimulus | BP |
| GO:0006816 | calcium ion transport | BP |
| GO:0004871 | signal transducer activity | MF |
| GO:0001726 | ruffle | CC |
| GO:0010243 | response to organic nitrogen | BP |
| GO:0030027 | lamellipodium | CC |
| GO:0005509 | calcium ion binding | MF |
| GO:0009629 | response to gravity | BP |
| GO:0005886 | plasma membrane | CC |
| GO:0032959 | inositol trisphosphate biosynthetic process | BP |
| GO:0035556 | intracellular signal transduction | BP |
| GO:0043278 | response to morphine | BP |
| GO:0009395 | phospholipid catabolic process | BP |
| GO:0010634 | positive regulation of epithelial cell migration | BP |
| GO:0009306 | protein secretion | BP |
>gi|6981370|ref|NP_037319.1| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 [Rattus norvegicus] MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIE GSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWL MEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDFEQRSGDITY GQFAQLYRSLMYSAQKTMDLPFLETNTLRTGERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSF LRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSL EAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSI KNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSSEKWFHGKLGAGRD GRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFD SLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPN SYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPD YGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW FPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLD VAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDM SSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMN QALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAE YDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAV PLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDF RISQEHLADHFDSRERRAPRRTRVNGDNRL |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.11243 |
| PDB |
1YWO 2FJL 1Y0M 1YWP 3GQI |
| RefSeq |
NP_037319.1 |
| Pfam |
PF00017 PF00388 PF00387 PF00169 PF09279 PF00168 PF00018 |