intercellular adhesion molecule 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term intercellular adhesion molecule 1
UniProt ID ICAM1_RAT
Name ICAM-1
Intercellular adhesion molecule 1
Gene Names Icam1
Taxonomy Rattus norvegicus

General annotation

Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
Subcellular location Membrane; Single-pass type I membrane protein.

Gene Ontology

GO:0051926 negative regulation of calcium ion transport BP
GO:0045429 positive regulation of nitric oxide biosynthetic process BP
GO:0071222 cellular response to lipopolysaccharide BP
GO:0045471 response to ethanol BP
GO:0071333 cellular response to glucose stimulus BP
GO:0042493 response to drug BP
GO:0034698 response to gonadotropin stimulus BP
GO:0031669 cellular response to nutrient levels BP
GO:0046688 response to copper ion BP
GO:0005615 extracellular space CC
GO:0045907 positive regulation of vasoconstriction BP
GO:0050900 leukocyte migration BP
GO:0007569 cell aging BP
GO:0010212 response to ionizing radiation BP
GO:0071356 cellular response to tumor necrosis factor BP
GO:0043498 cell surface binding MF
GO:0010477 response to sulfur dioxide BP
GO:0071347 cellular response to interleukin-1 BP
GO:0051092 positive regulation of NF-kappaB transcription factor activity BP
GO:0043200 response to amino acid stimulus BP
GO:0071312 cellular response to alkaloid BP
GO:0071456 cellular response to hypoxia BP
GO:0016021 integral to membrane CC
GO:0005178 integrin binding MF
GO:0001541 ovarian follicle development BP
GO:0014070 response to organic cyclic compound BP
GO:0008360 regulation of cell shape BP
GO:0001975 response to amphetamine BP

Sequence

>gi|6981068|ref|NP_037099.1| intercellular adhesion molecule 1 precursor [Rattus norvegicus]
MASTRARPMLPLLLVLVAVVIPGPVGAQVSIHPTEAFLPRGGSVQVNCSSSCEDENLGLGLETNWMKDEL
SSGHNWKLFKLSDIGEDSRPLCFENCGTTQSSASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGG
APRTQLSVVLLRGNETLSRQAVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLR
TFDLPTRVLKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASVEVTE
KLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEAHGGAQVVLLNSTSPRP
PTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKSLFKNQTLELHVLYGPHLDKKDCLGNWTW
QEGSQQTLTCQPQGNPAPNLTCSRKADGVPLPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHD
QNTWVIIVGVLVLIIAGFVIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000028066
UniGene Rn.12
PDB
RefSeq NP_037099.1
Pfam PF03921