phosphoinositide phospholipase C

General Information (Source: NCBI Gene,UniProt)

Text mining Term phosphoinositide phospholipase C
UniProt ID PLCB1_RAT
Name PLC-beta-1
PLC-I
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
PLC-154
Phospholipase C-beta-1
Phospholipase C-I
Phosphoinositide phospholipase C-beta-1
Gene Names Plcb1
Taxonomy Rattus norvegicus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular location Cytoplasm. Membrane. Note=And particulate fractions.

Gene Ontology

GO:0016042 lipid catabolic process BP
GO:0005624 membrane fraction CC
GO:0010243 response to organic nitrogen BP
GO:0016607 nuclear speck CC
GO:0035724 CD24 biosynthetic process BP
GO:0005509 calcium ion binding MF
GO:0045893 positive regulation of transcription, DNA-dependent BP
GO:0043434 response to peptide hormone stimulus BP
GO:0004871 signal transducer activity MF
GO:0007612 learning BP
GO:0004435 phosphatidylinositol phospholipase C activity MF
GO:0042803 protein homodimerization activity MF
GO:0007613 memory BP
GO:0032735 positive regulation of interleukin-12 production BP
GO:2000438 negative regulation of monocyte extravasation BP
GO:0016020 membrane CC
GO:0048009 insulin-like growth factor receptor signaling pathway BP
GO:0034284 response to monosaccharide stimulus BP
GO:0051318 G1 phase BP
GO:0007215 glutamate signaling pathway BP
GO:0060466 activation of meiosis involved in egg activation BP
GO:0045663 positive regulation of myoblast differentiation BP
GO:0005829 cytosol CC
GO:0035556 intracellular signal transduction BP
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway BP
GO:0046488 phosphatidylinositol metabolic process BP
GO:0021987 cerebral cortex development BP
GO:0048639 positive regulation of developmental growth BP
GO:0045892 negative regulation of transcription, DNA-dependent BP

Sequence

>gi|117647200|ref|NP_001071109.1| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 [Rattus norvegicus]
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVK
DARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATN
LLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPD
VYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEP
NSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYR
QVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTY
SDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKK
RNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVD
LAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVD
MFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPG
YHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTI
EELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEP
SSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQ
NNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKR
QEKLVEKHKEIRQQILDEKPKLQMELEQEYQDKFKRLPLEILEFVQEAMKGKVSEDSNHGSAPPSLASDP
AKVNLKSPSSEEVQGENAGREFDTPL

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene ENSRNOT00000051184
UniGene Rn.45523
PDB
RefSeq NP_001071109.1
Pfam PF00387
PF08703
PF09279
PF00168
PF00388
PF06631