phosphoinositide phospholipase C

General Information (Source: NCBI Gene,UniProt)

Text mining Term phosphoinositide phospholipase C
UniProt ID PLCD1_RAT
Name PLC-III
Phospholipase C-III
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
PLC-delta-1
Phosphoinositide phospholipase C-delta-1
Phospholipase C-delta-1
Gene Names Plcd1
Taxonomy Rattus norvegicus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
Subcellular location

Gene Ontology

GO:0016042 lipid catabolic process BP
GO:0004435 phosphatidylinositol phospholipase C activity MF
GO:0005634 nucleus CC
GO:0010044 response to aluminum ion BP
GO:0005829 cytosol CC
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process BP
GO:0051592 response to calcium ion BP
GO:0043434 response to peptide hormone stimulus BP
GO:0045121 membrane raft CC
GO:0005515 protein binding MF
GO:0004871 signal transducer activity MF
GO:0010243 response to organic nitrogen BP
GO:0005624 membrane fraction CC
GO:0005509 calcium ion binding MF
GO:0031966 mitochondrial membrane CC
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding MF
GO:0051482 elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger BP
GO:0034696 response to prostaglandin F stimulus BP
GO:0055093 response to hyperoxia BP
GO:0010701 positive regulation of norepinephrine secretion BP

Sequence

>gi|8393981|ref|NP_058731.1| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 [Rattus norvegicus]
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIE
DIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQK
LQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQ
RAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLL
SADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQ
EPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDG
VTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVP
ELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSS
NYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPER
LRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALV
RFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.12324
PDB 1DJW
1DJI
1DJX
1DJH
2ISD
1MAI
1DJZ
1DJY
1DJG
1QAT
1QAS
RefSeq NP_058731.1
Pfam PF00169
PF00168
PF09279
PF00387
PF00388