phospholipase C beta 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term phospholipase C beta 2
UniProt ID PLCB2_MOUSE
Name Phospholipase C-beta-2
Phosphoinositide phospholipase C-beta-2
PLC-beta-2
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Gene Names Plcb2
Taxonomy Mus musculus

General annotation

Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity).
Subcellular location

Gene Ontology

GO:0004435 phosphatidylinositol phospholipase C activity MF
GO:0005509 calcium ion binding MF
GO:0016042 lipid catabolic process BP
GO:0004871 signal transducer activity MF

Sequence

>gi|61676179|ref|NP_808236.2| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 [Mus musculus]
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFG
KFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTV
NAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKS
FLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGIN
VQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLL
SGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVP
VEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFI
SFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVA
LNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSV
RTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIP
INALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGS
LPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKEL
RELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELK
DRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLER
IQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKAL
AEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000102524
UniGene Mm.215156
PDB
RefSeq NP_808236.2
Pfam PF09279
PF08703
PF00388
PF00168
PF00387