Angiopoietin 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term Angiopoietin 2
UniProt ID ANGP2_RAT
Name Angiopoietin-2
ANG-2
Gene Names Angpt2
Synonyms:Agpt2
Taxonomy Rattus norvegicus

General annotation

Function Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Subcellular location Secreted.

Gene Ontology

GO:0009612 response to mechanical stimulus BP
GO:0009314 response to radiation BP
GO:0005634 nucleus CC
GO:0042995 cell projection CC
GO:0014070 response to organic cyclic compound BP
GO:0005615 extracellular space CC
GO:0007281 germ cell development BP
GO:0001666 response to hypoxia BP
GO:0001525 angiogenesis BP
GO:0046872 metal ion binding MF
GO:0045766 positive regulation of angiogenesis BP
GO:0060135 maternal process involved in female pregnancy BP
GO:0005886 plasma membrane CC
GO:0071363 cellular response to growth factor stimulus BP
GO:0014823 response to activity BP
GO:0009749 response to glucose stimulus BP
GO:0031100 organ regeneration BP

Sequence

>gi|198278529|ref|NP_604449.1| angiopoietin-2 precursor [Rattus norvegicus]
MWQIVFLTFGCDLVLASAYNNFRKSVDSTGRRQYQVQNGPCSYTFLLPETDSCRSSSSPYMSNAVQRDAP
LDYDDSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTR
KLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHSVQLQSMK
EQKDQLQVLVSKQSSVIDELEKKLVTATVNNSVLQKQQHDLMETVNSLLTMMSSPDYKSSVAVPKEEKTT
FRDCAEIFKSGLTTSGIYTLTFPNSTEEVKAYCDMDMGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPL
GEYWLGNEFVSQLTSGHRYVLKIQLKDWEGSEAHSLYEHFYLSGEESNYRIHLTGLTGTAGKISSISQPG
SDFSTKDSDNDKCICKCSQMLTGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMM
IRPADF

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000022774
UniGene Rn.138360
PDB
RefSeq NP_604449.1
Pfam PF00147