NADPH cytochrome P450 reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term NADPH cytochrome P450 reductase
UniProt ID NCPR_RAT
Name CPR
P450R
NADPH--cytochrome P450 reductase
Gene Names Por
Taxonomy Rattus norvegicus

General annotation

Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Subcellular location Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Anchored to the ER membrane by its N- terminal hydrophobic region.

Gene Ontology

GO:0019899 enzyme binding MF
GO:0005792 microsome CC
GO:0005506 iron ion binding MF
GO:0009812 flavonoid metabolic process BP
GO:0007584 response to nutrient BP
GO:0050661 NADP binding MF
GO:0003958 NADPH-hemoprotein reductase activity MF
GO:0046210 nitric oxide catabolic process BP
GO:0009055 electron carrier activity MF
GO:0050660 flavin adenine dinucleotide binding MF
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process BP
GO:0043066 negative regulation of apoptotic process BP
GO:0070988 demethylation BP
GO:0071375 cellular response to peptide hormone stimulus BP
GO:0032332 positive regulation of chondrocyte differentiation BP
GO:0043602 nitrate catabolic process BP
GO:0016787 hydrolase activity MF
GO:0010181 FMN binding MF
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation BP
GO:0047726 iron-cytochrome-c reductase activity MF
GO:0090031 positive regulation of steroid hormone biosynthetic process BP
GO:0004128 cytochrome-b5 reductase activity MF
GO:0071372 cellular response to follicle-stimulating hormone stimulus BP
GO:0060192 negative regulation of lipase activity BP
GO:0005739 mitochondrion CC
GO:0005789 endoplasmic reticulum membrane CC
GO:0045542 positive regulation of cholesterol biosynthetic process BP
GO:0019395 fatty acid oxidation BP
GO:0018393 internal peptidyl-lysine acetylation BP
GO:0042493 response to drug BP
GO:0045880 positive regulation of smoothened signaling pathway BP
GO:0009437 carnitine metabolic process BP

Sequence

>gi|13928780|ref|NP_113764.1| NADPH--cytochrome P450 reductase [Rattus norvegicus]
MGDSHEDTSATMPEAVAEEVSLFSTTDMVLFSLIVGVLTYWFIFRKKKEEIPEFSKIQTTAPPVKESSFV
EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATY
GEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDG
NLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKN
PFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNN
LDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWV
VEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVA
TSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGET
LLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVC
GDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000001961
UniGene Rn.11359
PDB 1JA1
1J9Z
3OJX
1JA0
3ES9
3OJW
1AMO
RefSeq NP_113764.1
Pfam PF00258
PF00175
PF00667