NADPH cytochrome P450 reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term NADPH cytochrome P450 reductase
UniProt ID NCPR_MOUSE
Name CPR
P450R
NADPH--cytochrome P450 reductase
Gene Names Por
Taxonomy Mus musculus

General annotation

Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Subcellular location Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Anchored to the ER membrane by its N- terminal hydrophobic region.

Gene Ontology

GO:0003958 NADPH-hemoprotein reductase activity MF
GO:0005506 iron ion binding MF
GO:0005792 microsome CC
GO:0005789 endoplasmic reticulum membrane CC
GO:0005625 soluble fraction CC

Sequence

>gi|6679421|ref|NP_032924.1| NADPH--cytochrome P450 reductase [Mus musculus]
MGDSHEDTSATVPEAVAEEVSLFSTTDIVLFSLIVGVLTYWFIFKKKKEEIPEFSKIQTTAPPVKESSFV
EKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATY
GEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDG
NLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYTGEMGRLKSYENQKPPFDAKN
PFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSTLVNQIGEILGADLDVIMSLNN
LDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWV
VEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVA
TSWLRTKEPAGENGRRALVPMFVRKSQFRLPFKPTTPVIMVGPGTGVAPFMGFIQERAWLREQGKEVGET
LLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDKEHLWKLIHEGGAHIYVC
GDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS

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Database Cross Reference

Ensembl Gene ENSMUST00000005651
UniGene Mm.3863
PDB
RefSeq NP_032924.1
Pfam PF00258
PF00667
PF00175