PGDH

General Information (Source: NCBI Gene,UniProt)

Text mining Term PGDH
UniProt ID PGDH_MOUSE
Name Prostaglandin dehydrogenase 1
15-hydroxyprostaglandin dehydrogenase [NAD+]
15-PGDH
Gene Names Hpgd
Synonyms:Pgdh1
Taxonomy Mus musculus

General annotation

Function Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Subcellular location Cytoplasm (By similarity).

Gene Ontology

GO:0007565 female pregnancy BP
GO:0030728 ovulation BP
GO:0070403 NAD+ binding MF
GO:0007179 transforming growth factor beta receptor signaling pathway BP
GO:0006693 prostaglandin metabolic process BP
GO:0004957 prostaglandin E receptor activity MF
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity MF
GO:0097070 ductus arteriosus closure BP
GO:0070493 thrombin receptor signaling pathway BP
GO:0005737 cytoplasm CC
GO:0007567 parturition BP
GO:0045786 negative regulation of cell cycle BP

Sequence

>gi|124486706|ref|NP_032304.2| 15-hydroxyprostaglandin dehydrogenase [NAD+] [Mus musculus]
MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQ
LRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLA
GLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQI
KAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene ENSMUST00000034026
UniGene Mm.18832
PDB
RefSeq NP_032304.2
Pfam PF00106