Nos 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term Nos 1
UniProt ID NANO1_MOUSE
Name NOS-1
Nanos homolog 1
Gene Names Nanos1
Synonyms:Nos
Taxonomy Mus musculus

General annotation

Function May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development.
Subcellular location Cytoplasm, perinuclear region (By similarity). Cytoplasm (By similarity). Note=Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells (By similarity).

Gene Ontology

GO:0048471 perinuclear region of cytoplasm CC
GO:0030371 translation repressor activity MF
GO:0003723 RNA binding MF
GO:0010631 epithelial cell migration BP
GO:0008270 zinc ion binding MF

Sequence

>gi|84872196|ref|NP_848508.2| nanos homolog 1 [Mus musculus]
MEAFPWAPRSPRRARAPAPMALVPSARYVSASGPVHPQPFSSWNDYLGLATLITRASDRGSPHEGPGPTA
AGPTMGPPEDDEDDDGEEPEAGGRYLGGALELRALELCAGPAEPGLLEERFAELNPFAGRAAAVLLGCAP
TASTTAAAASTAEVTPREEPSPAWAAEPRLHAASGATAARLLKPELQVCVFCRNNKEAVALYTTHILKGP
DGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPTVRPPPRSNRDSLPSKKLR

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Database Cross Reference

Ensembl Gene ENSMUST00000088237
UniGene Mm.186390
PDB
RefSeq NP_848508.2
Pfam PF05741