glyceraldehyde 3 phosphate dehydrogenase

General Information (Source: NCBI Gene,UniProt)

Text mining Term glyceraldehyde 3 phosphate dehydrogenase
UniProt ID G3P_RAT
Name Glyceraldehyde-3-phosphate dehydrogenase
BARS-38
GAPDH
Peptidyl-cysteine S-nitrosylase GAPDH
38 kDa BFA-dependent ADP-ribosylation substrate
Gene Names Gapdh
Synonyms:Gapd
Taxonomy Rattus norvegicus

General annotation

Function Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
Subcellular location Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.

Gene Ontology

GO:0005515 protein binding MF
GO:0005634 nucleus CC
GO:0035606 peptidyl-cysteine S-trans-nitrosylation BP
GO:0060359 response to ammonium ion BP
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity MF
GO:0050661 NADP binding MF
GO:0006096 glycolysis BP
GO:0035605 peptidyl-cysteine S-nitrosylase activity MF
GO:0005829 cytosol CC
GO:0051402 neuron apoptosis BP
GO:0050821 protein stabilization BP
GO:0005625 soluble fraction CC
GO:0006094 gluconeogenesis BP
GO:0051287 NAD binding MF

Sequence

>gi|8393418|ref|NP_058704.1| glyceraldehyde-3-phosphate dehydrogenase [Rattus norvegicus]
MVKVGVNGFGRIGRLVTRAAFSCDKVDIVAINDPFIDLNYMVYMFQYDSTHGKFNGTVKAENGKLVINGK
PITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDN
SLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTG
AAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQAAEGPLKGILGYTEDQVV
SCDFNSNSHSSTFDAGAGIALNDNFVKLISWYDNEYGYSNRVVDLMAYMASKE

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Database Cross Reference

Ensembl Gene ENSRNOT00000050443
UniGene Rn.91450
Rn.129558
PDB
RefSeq NP_058704.1
XP_001062726.1
XP_002726600.1
Pfam PF02800
PF00044