caspase 2

General Information (Source: NCBI Gene,UniProt)

Text mining Term caspase 2
UniProt ID CASP2_RAT
Name Caspase-2
Caspase-2 subunit p12
CASP-2
Protease ICH-1
Caspase-2 subunit p13
Caspase-2 subunit p18
Gene Names Casp2
Synonyms:Ich1
Taxonomy Rattus norvegicus

General annotation

Function Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity).
Subcellular location

Gene Ontology

GO:0043525 positive regulation of neuron apoptosis BP
GO:0005739 mitochondrion CC
GO:0005625 soluble fraction CC
GO:0003407 neural retina development BP
GO:0006915 apoptotic process BP
GO:0007420 brain development BP
GO:0007568 aging BP
GO:0005624 membrane fraction CC
GO:0001554 luteolysis BP
GO:0006508 proteolysis BP

Sequence

>gi|19923687|ref|NP_071967.2| caspase-2 [Rattus norvegicus]
MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEM
RELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSL
PFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHF
TGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE
GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGK
EELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGY
APGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000022672
UniGene Rn.1438
PDB
RefSeq NP_071967.2
Pfam PF00619
PF00656