vitamin D binding protein

General Information (Source: NCBI Gene,UniProt)

Text mining Term vitamin D binding protein
UniProt ID VTDB_MOUSE
Name Group-specific component
DBP
VDB
Vitamin D-binding protein
Gc-globulin
Gene Names Gc
Taxonomy Mus musculus

General annotation

Function Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
Subcellular location Secreted.

Gene Ontology

GO:0051183 vitamin transporter activity MF
GO:0042359 vitamin D metabolic process BP
GO:0003779 actin binding MF
GO:0005499 vitamin D binding MF

Sequence

>gi|51172612|ref|NP_032122.1| vitamin D-binding protein precursor [Mus musculus]
MKRVLVLLLALAFGHALERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSL
TEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPT
NDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLS
LLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPE
HTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFEL
SRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKK
KLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000049209
UniGene Mm.196595
PDB
RefSeq NP_032122.1
Pfam PF09164
PF00273