semicarbazide sensitive amine oxidase

General Information (Source: NCBI Gene,UniProt)

Text mining Term semicarbazide sensitive amine oxidase
UniProt ID AOC3_RAT
Name Membrane primary amine oxidase
Copper amine oxidase
SSAO
VP97
Semicarbazide-sensitive amine oxidase
VAP-1
Vascular adhesion protein 1
Gene Names Aoc3
Taxonomy Rattus norvegicus

General annotation

Function Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity).
Subcellular location Membrane; Single-pass type II membrane protein.

Gene Ontology

GO:0002523 leukocyte migration involved in inflammatory response BP
GO:0005615 extracellular space CC
GO:0052595 aliphatic-amine oxidase activity MF
GO:0008131 primary amine oxidase activity MF
GO:0007568 aging BP
GO:0007155 cell adhesion BP
GO:0005507 copper ion binding MF
GO:0052594 aminoacetone MF
GO:0042755 eating behavior BP
GO:0042803 protein homodimerization activity MF
GO:0002687 positive regulation of leukocyte migration BP
GO:0008217 regulation of blood pressure BP
GO:0052596 phenethylamine MF
GO:0005886 plasma membrane CC
GO:0052593 tryptamine MF
GO:0009308 amine metabolic process BP
GO:0016021 integral to membrane CC
GO:0005792 microsome CC
GO:0048038 quinone binding MF
GO:0002675 positive regulation of acute inflammatory response BP
GO:0010828 positive regulation of glucose transport BP
GO:0009986 cell surface CC

Sequence

>gi|71896590|ref|NP_113770.2| membrane primary amine oxidase [Rattus norvegicus]
MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTA
VMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSE
LVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLK
MTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDM
FEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIF
DIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQ
TPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFH
ATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQ
RLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRY
HLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNG
VGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.198327
PDB
RefSeq NP_113770.2
Pfam PF01179
PF02728
PF02727