vitamin D binding protein

General Information (Source: NCBI Gene,UniProt)

Text mining Term vitamin D binding protein
UniProt ID VTDB_RAT
Name VDB
DBP
Vitamin D-binding protein
Gc-globulin
Group-specific component
Gene Names Gc
Synonyms:Dbp
Taxonomy Rattus norvegicus

General annotation

Function Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
Subcellular location Secreted.

Gene Ontology

GO:0005499 vitamin D binding MF
GO:0007565 female pregnancy BP
GO:0005829 cytosol CC
GO:0031667 response to nutrient levels BP
GO:0032355 response to estradiol stimulus BP
GO:0048471 perinuclear region of cytoplasm CC
GO:0007595 lactation BP
GO:0051183 vitamin transporter activity MF
GO:0030424 axon CC
GO:0003779 actin binding MF
GO:0005615 extracellular space CC

Sequence

>gi|6978879|ref|NP_036696.1| vitamin D-binding protein precursor [Rattus norvegicus]
MKRVLVLLLALAFGHALERGRDYEKDKVCQELSTLGKDDFRSLSLILYSRKFPSSTFEQVSQLVKEVVSL
TEECCAEGADPNCYDTRTSELSIKSCESDAPFPVHPGTSECCTKEGLERKLCMAALSHQPQEFPAYVEPT
NDEICEAFRKDPKGFADQFLFEYSSNYGQAPLPLLVGYTKSYLSMVGSCCTSAKPTVCFLKERLQMKQLL
LLTTMSNRVCSQYAAYGKEKSRMSHLIKLAQKVPTANLEDVLPLAEDLTEILSRCCKSTSEDCMARELPE
HTLKICGNLSKKNSKFEECCYETTPMGIFMCSYFMPTAEPLQLPAIKLPTSKDLCGQSATQAMDQYTFEL
SRRTQVPEVFLSKVLDTTLKTLRECCDTQDSVSCFSTQSPLMKRQLTSFIEKGQEMCADYSENTFTEYKK
KLAERLRTKMPNASPEELADMVAKHSDFASKCCSINSPPRYCSSQIDAEMRDILQS

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Database Cross Reference

Ensembl Gene
UniGene Rn.1437
PDB
RefSeq NP_036696.1
Pfam PF09164
PF00273