SNAP 25

General Information (Source: NCBI Gene,UniProt)

Text mining Term SNAP 25
UniProt ID SNP25_RAT
Name SNAP-25
Synaptosomal-associated 25 kDa protein
Super protein
Synaptosomal-associated protein 25
SUP
Gene Names Snap25
Synonyms:Snap
Taxonomy Rattus norvegicus

General annotation

Function t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Subcellular location Cytoplasm, perinuclear region (By similarity). Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity).

Gene Ontology

GO:0005484 SNAP receptor activity MF
GO:0030027 lamellipodium CC
GO:0005768 endosome CC
GO:0005625 soluble fraction CC
GO:0007409 axonogenesis BP
GO:0007616 long-term memory BP
GO:0045202 synapse CC
GO:0008076 voltage-gated potassium channel complex CC
GO:0030431 sleep BP
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex CC
GO:0047485 protein N-terminus binding MF
GO:0016197 endosome transport BP
GO:0045121 membrane raft CC
GO:0015629 actin cytoskeleton CC
GO:0019717 synaptosome CC
GO:0044295 axonal growth cone CC
GO:0051963 regulation of synapse assembly BP
GO:0032024 positive regulation of insulin secretion BP
GO:0019904 protein domain specific binding MF
GO:0043025 neuronal cell body CC
GO:0005249 voltage-gated potassium channel activity MF
GO:0006887 exocytosis BP
GO:0017022 myosin binding MF
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter BP
GO:0030252 growth hormone secretion BP
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex CC
GO:0030175 filopodium CC
GO:0048471 perinuclear region of cytoplasm CC
GO:0017075 syntaxin-1 binding MF
GO:0030054 cell junction CC

Sequence

>gi|13591882|ref|NP_112253.1| synaptosomal-associated protein 25 [Rattus norvegicus]
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKD
MKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTND
ARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG

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Database Cross Reference

Ensembl Gene
UniGene Rn.107689
PDB 3HD7
1URQ
1N7S
3IPD
1JTH
1SFC
RefSeq NP_112253.1
Pfam PF00835
PF05739