histamine H2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term histamine H2 receptor
UniProt ID HRH2_RAT
Name HH2R
Histamine H2 receptor
Gastric receptor I
H2R
Gene Names Hrh2
Taxonomy Rattus norvegicus

General annotation

Function The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0005886 plasma membrane CC
GO:0004969 histamine receptor activity MF
GO:0016021 integral to membrane CC

Sequence

>gi|94400879|ref|NP_037097.3| histamine H2 receptor [Rattus norvegicus]
MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLL
VLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLV
FIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIARE
QAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANS
ALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELT
HPQGNPIR

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.138113
PDB
RefSeq NP_037097.3
Pfam PF00001