beta endorphin

General Information (Source: NCBI Gene,UniProt)

Text mining Term beta endorphin
UniProt ID COLI_MOUSE
Name Met-enkephalin
Gamma-MSH
ACTH
Lipotropin beta
Adrenocorticotropic hormone
Beta-MSH
Beta-LPH
Alpha-MSH
Pro-opiomelanocortin
Melanotropin alpha
Melanotropin beta
Melanotropin gamma
POMC
Corticotropin
NPP
Corticotropin-like intermediary peptide
Corticotropin-lipotropin
Beta-endorphin
Gamma-LPH
Lipotropin gamma
CLIP
Gene Names Pomc
Synonyms:Pomc1
Taxonomy Mus musculus

General annotation

Function ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates.
Subcellular location Secreted (By similarity).

Gene Ontology

GO:0005615 extracellular space CC
GO:0030141 secretory granule CC
GO:0006091 generation of precursor metabolites and energy BP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter BP
GO:0007218 neuropeptide signaling pathway BP
GO:0005179 hormone activity MF
GO:0032098 regulation of appetite BP
GO:0070996 type 1 melanocortin receptor binding MF
GO:0007267 cell-cell signaling BP
GO:0033059 cellular pigmentation BP
GO:0032720 negative regulation of tumor necrosis factor production BP

Sequence

>gi|6679415|ref|NP_032921.1| pro-opiomelanocortin precursor [Mus musculus]
MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPL
TENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKR
RPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMT
SEKSQTPLVTLFKNAIIKNAHKKGQ

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSMUST00000020990
UniGene Mm.277996
PDB
RefSeq NP_032921.1
Pfam PF00976
PF08384
PF08035