cytochrome P450 2E1

General Information (Source: NCBI Gene,UniProt)

Text mining Term cytochrome P450 2E1
UniProt ID CP2E1_RAT
Name 4-nitrophenol 2-hydroxylase
Cytochrome P450-J
Cytochrome P450 2E1
CYPIIE1
Cytochrome P450RLM6
Gene Names Cyp2e1
Taxonomy Rattus norvegicus

General annotation

Function Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites (By similarity).
Subcellular location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology

GO:0010181 FMN binding MF
GO:0009055 electron carrier activity MF
GO:0020037 heme binding MF
GO:0042493 response to drug BP
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen MF
GO:0006641 triglyceride metabolic process BP
GO:0006805 xenobiotic metabolic process BP
GO:0010243 response to organic nitrogen BP
GO:0010193 response to ozone BP
GO:0005739 mitochondrion CC
GO:0005792 microsome CC
GO:0045471 response to ethanol BP
GO:0000139 Golgi membrane CC
GO:0031227 intrinsic to endoplasmic reticulum membrane CC
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen MF

Sequence

>gi|13928734|ref|NP_113731.1| cytochrome P450 2E1 [Rattus norvegicus]
MAVLGITIALLVWVATLLVISIWKKIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTL
HLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGK
QGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLL
STPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQ
EPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYM
DAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVI
PRS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000016883
UniGene Rn.1372
PDB
RefSeq NP_113731.1
Pfam PF00067