cytochrome P450 2E1

General Information (Source: NCBI Gene,UniProt)

Text mining Term	cytochrome P450 2E1
UniProt ID	CP2E1_MOUSE
Name	Cytochrome P450-ALC Cytochrome P450 2E1 4-nitrophenol 2-hydroxylase CYPIIE1 Cytochrome P450-J
Gene Names	Cyp2e1
Taxonomy	Mus musculus

General annotation

Function	Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites (By similarity).
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology

GO:0020037	heme binding	MF
GO:0005792	microsome	CC
GO:0009055	electron carrier activity	MF
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	MF

Sequence

>gi|11276065|ref|NP_067257.1| cytochrome P450 2E1 [Mus musculus]
MAVLGITVALLVWIATLLLVSIWKQIYRSWNLPPGPFPIPFFGNIFQLDLKDIPKSLTKLAKRFGPVFTL
HLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGK
QGNEARIQREAHFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENFYLL
STPWIQAYNYFSDYLQYLPGSHRKVMKNVSEIRQYTLGKAKEHLKSLDINCPRDVTDCLLIEMEKEKHSQ
EPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRAPAVRDRMNMPYM
DAVVHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTIGFGSIPREFKLCVI
PRS

Database Cross Reference

Ensembl Gene	ENSMUST00000026552
UniGene	Mm.21758
PDB
RefSeq	NP_067257.1
Pfam	PF00067

PTID

cytochrome P450 2E1

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference