lipophilin

General Information (Source: NCBI Gene,UniProt)

Text mining Term lipophilin
UniProt ID MYPR_RAT
Name PLP
Myelin proteolipid protein
Lipophilin
Gene Names Plp1
Synonyms:Plp
Taxonomy Rattus norvegicus

General annotation

Function This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0019911 structural constituent of myelin sheath MF
GO:0005887 integral to plasma membrane CC
GO:0007229 integrin-mediated signaling pathway BP

Sequence

>gi|13591880|ref|NP_112252.1| myelin proteolipid protein [Rattus norvegicus]
MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQY
VIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCH
CLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVL
PWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000003283
UniGene Rn.4550
PDB
RefSeq NP_112252.1
Pfam PF01275