hydroxymethylbilane synthase

General Information (Source: NCBI Gene,UniProt)

Text mining Term hydroxymethylbilane synthase
UniProt ID HEM3_SCHPO
Name Hydroxymethylbilane synthase
Porphobilinogen deaminase
Pre-uroporphyrinogen synthase
HMBS
PBG
Gene Names hem3
Taxonomy Schizosaccharomyces pombe 972h-

General annotation

Function Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity).
Subcellular location

Gene Ontology

GO:0018160 peptidyl-pyrromethane cofactor linkage BP
GO:0005634 nucleus CC
GO:0005737 cytoplasm CC
GO:0006783 heme biosynthetic process BP
GO:0004418 hydroxymethylbilane synthase activity MF

Sequence

>gi|67989478|ref|NP_001018179.1| hydroxymethylbilane synthase [Schizosaccharomyces pombe 972h-]
MPSCTSFPIGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTREL
EALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPPGSVVGTSSIRRR
ALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGLKDRIAQMLTAPFVYYAVGQGAL
AVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQGGCAIPIGVQTDVLAISNSSYRISLLGTVLSA
DGLRAAFGNAEAVVSSEEEAEELGITVALALLKNGAGPILEEHQRSSDSEESLKNY

Options for BLAST

Database:

Set subsequence:(optional):
From: To:

Optional parameters:
Expect:
Descriptions:

Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq NP_001018179.1
Pfam PF03900
PF01379