thrombin

General Information (Source: NCBI Gene,UniProt)

Text mining Term thrombin
UniProt ID SCA_DROME
Name Protein scabrous
Gene Names sca
Taxonomy Drosophila melanogaster

General annotation

Function Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.
Subcellular location Late endosome. Note=Colocalizes in late endosomes with Gp150.

Gene Ontology

GO:0005102 receptor binding MF
GO:0007219 Notch signaling pathway BP
GO:0007460 R8 cell fate commitment BP
GO:0004871 signal transducer activity MF
GO:0046331 lateral inhibition BP
GO:0016321 female meiosis chromosome segregation BP
GO:0016318 ommatidial rotation BP
GO:0005770 late endosome CC
GO:0045468 regulation of R8 cell spacing in compound eye BP
GO:0008587 imaginal disc-derived wing margin morphogenesis BP
GO:0005615 extracellular space CC

Sequence

>gi|37999914|sp|P21520.3|SCA_DROME RecName: Full=Protein scabrous; Flags: Precursor
MRDWQTFPDLQKKKVSRDHLNCPATMAGSNVLWPILLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAK
VVTSEKPVVHSKQETEAPESSVELLRFVDDDEDSEDISSIERQDGRTMESKKMADQVRLLTKQLNALMLR
RREDYEMLEHNLRKSLRLTTNANSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQL
VDLQRTASNVAQDVQQRSSTFEDLATIRSDYQQLKLDLAAQRERQQQTEVYVQELREEMLQQEQDFQHAL
VKLQQRTRKDGSSASVEEESGSQEANQEQTGLETTADHKRRHCRFQSEQIHQLQLAQRNLRRQVNGLRFH
HIDERVRSIEVEQHRIANANFNLSSQIASLDKLHTSMLELLEDVEGLQTKMDKSIPELRHEISKLEFANA
QITSEQSLIREEGTNAARSLQAMAVSVSVLQEEREGMRKLSANVDQLRTNVDRLQSLVNDEMKNKLTHLN
KPHKRPHHQNVQAQMPQDDSPIDSVLAETLVSELENVETQYEAIINKLPHDCSEVHTQTDGLHLIAPAGQ
RHPLMTHCTADGWTTVQRRFDGSADFNRSWADYAQGFGAPGGEFWIGNEQLHHLTLDNCSRLQVQMQDIY
DNVWVAEYKRFYISSRADGYRLHIAEYSGNASDALNYQQGMQFSAIDDDRDISQTHCAANYEGGWWFSHC
QHANLNGRYNLGLTWFDAARNEWIAVKSSRMLVKRLPAVECQANASASGAFVSVSGSAADAAPSSGATTT
TTTATAAPATVTTPKTNNSVVQFVAAGQA

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Database Cross Reference

Ensembl Gene
UniGene Dm.4735
PDB
RefSeq NP_725230.2
NP_476710.2
Pfam PF00147