protein kinase C (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term protein kinase C (protein family or complex)
UniProt ID KPC2_DROME
Name Protein kinase C, eye isozyme
dPKC53E(EY)
Inactivation no after-potential C protein
Photoreceptor-specific PKC
Protein INAC
Eye-PKC
Gene Names inaC
Synonyms:PKC2
Taxonomy Drosophila melanogaster

General annotation

Function This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD.
Subcellular location

Gene Ontology

GO:0006928 cellular component movement BP
GO:0019722 calcium-mediated signaling BP
GO:0016059 deactivation of rhodopsin mediated signaling BP
GO:0030845 inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway BP
GO:0008585 female gonad development BP
GO:0016027 inaD signaling complex CC
GO:0005524 ATP binding MF
GO:0005515 protein binding MF
GO:0008270 zinc ion binding MF
GO:0016062 adaptation of rhodopsin mediated signaling BP
GO:0004697 protein kinase C activity MF
GO:0045471 response to ethanol BP
GO:0006911 phagocytosis, engulfment BP

Sequence

>gi|17136716|ref|NP_476863.1| inactivation no afterpotential C [Drosophila melanogaster]
MAAAAVATPGATVLPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVN
GHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWI
STTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKV
DIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVW
DWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRR
MDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEK
KILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERD
IIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLL
FEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFR
NVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFITII

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.4688
PDB
RefSeq NP_476863.1
Pfam PF00433
PF00069
PF00130
PF00168