cytochrome c

General Information (Source: NCBI Gene,UniProt)

Text mining Term cytochrome c
UniProt ID E5LMI2_9HEMI
Name Cytochrome c oxidase subunit 1
Gene Names COI
Taxonomy Lipaphis erysimi

General annotation

Function Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
Subcellular location Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0009060 aerobic respiration BP
GO:0004129 cytochrome-c oxidase activity MF
GO:0022900 electron transport chain BP
GO:0009055 electron carrier activity MF
GO:0020037 heme binding MF
GO:0005743 mitochondrial inner membrane CC
GO:0070469 respiratory chain CC
GO:0016021 integral to membrane CC

Sequence

>gi|312983818|gb|ADR30577.1| cytochrome c oxidase subunit I [Lipaphis erysimi]
NISVDLTIFSLHLAGISSILGAINFICTILNMMPNNMKLNQIPLFPWSILITAILLILSLPVLAGAITML
LTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGLISHIISQESNKNETFGNISMIYAMLT
IGLLGFIVWAHHMFTIGMDVDTRAYFTSATMIIAIPTGIKIFSWLATIYGSKINFSPSTIWSLGFIFLFT
IGGLTGVILANSSIDIILHDTYYVVAHFHYVLSMGIVFAIIASLIHWFPIFTGFYMNNFILKIQFILMFI
GVNLTFFPQHFLGLNGMPRRYTDYPNNFLL

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam PF00115