| Text mining Term | PARP |
|---|---|
| UniProt ID | PARP_DROME |
| Name |
NAD(+) ADP-ribosyltransferase PARP Poly[ADP-ribose] synthase Poly [ADP-ribose] polymerase ADPRT |
| Gene Names |
Parp
|
| Taxonomy | Drosophila melanogaster |
| Function |
Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. Plays a fundamental role in organizing chromatin on a global scale; isoform e autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment. |
|---|---|
| Subcellular location |
Nucleus. Nucleus, nucleolus. Note=Highly enriched in nucleoli, heterochromatic chromosomal regions, and diverse euchromatic sites in the cells of most embryonic and adult tissues. |
| GO:0045087 | innate immune response | BP |
| GO:0005703 | polytene chromosome puff | CC |
| GO:0035080 | heat shock-mediated polytene chromosome puffing | BP |
| GO:0009303 | rRNA transcription | BP |
| GO:0006963 | positive regulation of antibacterial peptide biosynthetic process | BP |
| GO:0051457 | maintenance of protein location in nucleus | BP |
| GO:0007552 | metamorphosis | BP |
| GO:0016568 | chromatin modification | BP |
| GO:0005730 | nucleolus | CC |
| GO:0042393 | histone binding | MF |
| GO:0006471 | protein ADP-ribosylation | BP |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | MF |
| GO:0008270 | zinc ion binding | MF |
| GO:0043484 | regulation of RNA splicing | BP |
| GO:0005719 | nuclear euchromatin | CC |
| GO:0006355 | regulation of transcription, DNA-dependent | BP |
| GO:0003677 | DNA binding | MF |
| GO:0051287 | NAD binding | MF |
| GO:0007000 | nucleolus organization | BP |
>gi|548585|sp|P35875.1|PARP_DROME RecName: Full=Poly [ADP-ribose] polymerase; Short=PARP; AltName: Full=NAD(+) ADP-ribosyltransferase; Short=ADPRT; AltName: Full=Poly[ADP-ribose] synthase MDIELPYLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFFKNQRPSSVGDIQNI GNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLALKDFGIEYAKSSRSTCRGCEQKINKDLVRLRKT VYDTEVGMKYGGQPLWHHLECFAQLRSELGWFASGEDMPGFQSLADDDQAKVKNAIPPIKSEELPDTKRA KMELSDTNEEGEKKQRLKDQNDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTGDTEKLFDQTADLLTFG AIESCSECNSCQFIVNKSGYICNGNHSEWTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIFN NFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIGLKNQHKELRKRIENLGGKFEVKISEN TIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEADTEGAIKYINSTCICSWGTDPKSRIPKETTK SLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLEDIAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKA DKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYD DDQKLVKHESHFFTSKLEISVQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYN VLECGSNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACN PLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRK LLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGD MMECTSAKYINKLSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQV NIQYLFRMEFKYSY |
| Ensembl Gene | |
|---|---|
| UniGene |
Dm.7847 |
| PDB | |
| RefSeq |
NP_001104452.1 |
| Pfam |
PF05406 PF00533 PF02877 PF00644 PF08063 PF00645 |