| Text mining Term | PARP |
|---|---|
| UniProt ID | PARP_DROME |
| Name |
NAD(+) ADP-ribosyltransferase ADPRT PARP Poly[ADP-ribose] synthase Poly [ADP-ribose] polymerase |
| Gene Names |
Parp
|
| Taxonomy | Drosophila melanogaster |
| Function |
Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. Plays a fundamental role in organizing chromatin on a global scale; isoform e autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment. |
|---|---|
| Subcellular location |
Nucleus. Nucleus, nucleolus. Note=Highly enriched in nucleoli, heterochromatic chromosomal regions, and diverse euchromatic sites in the cells of most embryonic and adult tissues. |
| GO:0035080 | heat shock-mediated polytene chromosome puffing | BP |
| GO:0006963 | positive regulation of antibacterial peptide biosynthetic process | BP |
| GO:0009303 | rRNA transcription | BP |
| GO:0005703 | polytene chromosome puff | CC |
| GO:0007000 | nucleolus organization | BP |
| GO:0006471 | protein ADP-ribosylation | BP |
| GO:0043484 | regulation of RNA splicing | BP |
| GO:0051457 | maintenance of protein location in nucleus | BP |
| GO:0005730 | nucleolus | CC |
| GO:0003677 | DNA binding | MF |
| GO:0008270 | zinc ion binding | MF |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | MF |
| GO:0042393 | histone binding | MF |
| GO:0051287 | NAD binding | MF |
| GO:0016568 | chromatin modification | BP |
| GO:0007552 | metamorphosis | BP |
| GO:0006355 | regulation of transcription, DNA-dependent | BP |
| GO:0045087 | innate immune response | BP |
| GO:0005719 | nuclear euchromatin | CC |
>gi|548585|sp|P35875.1|PARP_DROME RecName: Full=Poly [ADP-ribose] polymerase; Short=PARP; AltName: Full=NAD(+) ADP-ribosyltransferase; Short=ADPRT; AltName: Full=Poly[ADP-ribose] synthase MDIELPYLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFFKNQRPSSVGDIQNI GNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLALKDFGIEYAKSSRSTCRGCEQKINKDLVRLRKT VYDTEVGMKYGGQPLWHHLECFAQLRSELGWFASGEDMPGFQSLADDDQAKVKNAIPPIKSEELPDTKRA KMELSDTNEEGEKKQRLKDQNDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTGDTEKLFDQTADLLTFG AIESCSECNSCQFIVNKSGYICNGNHSEWTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIFN NFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIGLKNQHKELRKRIENLGGKFEVKISEN TIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEADTEGAIKYINSTCICSWGTDPKSRIPKETTK SLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLEDIAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKA DKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYD DDQKLVKHESHFFTSKLEISVQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYN VLECGSNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACN PLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRK LLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGD MMECTSAKYINKLSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQV NIQYLFRMEFKYSY |
| Ensembl Gene | |
|---|---|
| UniGene |
Dm.7847 |
| PDB | |
| RefSeq |
NP_001104452.1 |
| Pfam |
PF08063 PF02877 PF00645 PF05406 PF00533 PF00644 |