eukaryotic translation initiation factor 5A

General Information (Source: NCBI Gene,UniProt)

Text mining Term eukaryotic translation initiation factor 5A
UniProt ID IF5A_NEUCR
Name eIF-5A
eIF-4D
Eukaryotic translation initiation factor 5A
Gene Names
Taxonomy Neurospora crassa OR74A

General annotation

Function mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity).
Subcellular location Cytoplasm (By similarity).

Gene Ontology

GO:0005737 cytoplasm CC
GO:0045901 positive regulation of translational elongation BP
GO:0003746 translation elongation factor activity MF
GO:0006452 translational frameshifting BP
GO:0008612 peptidyl-lysine modification to hypusine BP
GO:0043022 ribosome binding MF
GO:0045905 positive regulation of translational termination BP

Sequence

>gi|164429238|ref|XP_961911.2| eukaryotic translation initiation factor 5A [Neurospora crassa OR74A]
MSAAHDDAQHEHTFDSVDAGASATYPMQCSALRKGGHVVIKNRPCKIVDMSTSKTGKHGHAKVHLVAIDI
FTGKKLEDLCPSTHNMDVPNVKRTDYQFSYIDEDFLVLIDSNGEEKRDVKMPEGELAKRIEKLEEEGKDF
FVGVQTAMGEEAAIDVKEASNKD

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Database Cross Reference

Ensembl Gene
UniGene Ncr.9233
PDB
RefSeq XP_961911.2
Pfam PF00467
PF01287