mitogen activated protein kinase (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term mitogen activated protein kinase (protein family or complex)
UniProt ID HOG1_CRYNJ
Name MAP kinase HOG1
Mitogen-activated protein kinase HOG1
Gene Names HOG1
Taxonomy Cryptococcus neoformans var. neoformans JEC21

General annotation

Function Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Also involved in response UV radiations and mediates the sensitivity to fludioxonil, an agricultural fungicide.
Subcellular location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.

Gene Ontology

GO:0006355 regulation of transcription, DNA-dependent BP
GO:0006351 transcription, DNA-dependent BP
GO:0005524 ATP binding MF
GO:0005634 nucleus CC
GO:0004707 MAP kinase activity MF
GO:0005737 cytoplasm CC

Sequence

>gi|58265586|ref|XP_569949.1| mitogen-activated protein kinase [Cryptococcus neoformans var. neoformans JEC21]
MADFVKLSIFGTVFEVTTRYVDLQPVGMGAFGLVCSAKDQLSGTSVAIKKIMKPFSTPVLSKRTYRELKL
LKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHR
DLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEG
KPLFPGKDHVNQFSIITELLGTPPDDVIQTIASENTLRFVQSLPKREKVPFSTKFPNADPVSLDLLEKML
VFDPRTRISAAEGLAHEYLAPYHDPTDEPVAAEVFDWSFNDADLPVDTWKVMMYSEILDFHNLGDISQNE
AEGPVTGEVPAAPAS

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Fne.6999
PDB
RefSeq XP_569949.1
Pfam PF00069