IgE

General Information (Source: NCBI Gene,UniProt)

Text mining Term IgE
UniProt ID MYR1_MYRPI
Name Allergen Myr p I
Pilosulin-1
Pilosulin-1 68->112
Major allergen Myr p 1
Pilosulin-1 86->112
Pilosulin-1
Pilosulin-1 71->112
Pilosulin-1 65->112
Gene Names
Taxonomy Myrmecia pilosula

General annotation

Function Has strong cytotoxic and hemolytic activities. Is more potent against mononuclear leukocytes than against granulocytes. The synthesized peptide 57-76 shows a potent and broad spectrum antimicrobial activity against both Gram-positive and Gram- negative bacteria, and also against the fungus C.albicans. Adopts an alpha-helical structure.
Subcellular location Secreted.

Gene Ontology

GO:0005576 extracellular region CC
GO:0050832 defense response to fungus BP
GO:0044179 hemolysis in other organism BP
GO:0042742 defense response to bacterium BP
GO:0019835 cytolysis BP

Sequence

>gi|730091|sp|Q07932.1|MYR1_MYRPI RecName: Full=Pilosulin-1; AltName: Full=Allergen Myr p I; AltName: Full=Major allergen Myr p 1; AltName: Allergen=Myr p 1; Contains: RecName: Full=Pilosulin-1; Contains: RecName: Full=Pilosulin-1 65->112; Contains: RecName: Full=Pilosulin-1 68->112; Contains: RecName: Full=Pilosulin-1 71->112; Contains: RecName: Full=Pilosulin-1 86->112; Flags: Precursor
MKLSCLLLTLTIIFVLTIVHAPNVEAKDLADPESEAVGFADAFGEADAVGEADPNAGLGSVFGRLARILG
RVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ

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Database Cross Reference

Ensembl Gene
UniGene
PDB
RefSeq
Pfam